Selank · research summary

Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission.

Frontiers in pharmacology · 2016. Summary drawn from the study's full text. Each statement is followed by the exact sentence it comes from. This is a research summary, not medical advice.

Study type

In vivo animal study investigating gene expression in rat frontal cortex using real-time PCR
“To test this hypothesis we studied the effect of Selank and GABA on the expression of genes involved in neurotransmission.”

Subjects

Male Wistar rats
“The male Wistar rats with an average weight of 200 g were used in the experiment.”

Sample size

30 rats divided into three groups of 10 (control, Selank, GABA)
“The animals (n = 30) were divided into three groups: one control group (n1 = 10) and two experimental groups: Selank group (n2 = 10) and GABA group (n3 = 10).”

Duration

Tissue samples collected 1 and 3 hours after administration
“The first half of animals from each group was decapitated 1 h after the administration of the compounds, the second half—after 3 h.”

Reported findings

Significant changes in the expression of 45 genes were observed 1 hour after administration of Selank or GABA
“We found significant changes in the expression of 45 genes 1 h after the administration of the compounds.”
A positive correlation was found between gene expression changes after Selank and GABA administration at 1 hour
“We found positive correlation between the changes in genes expression within 1 h after administration of Selank or GABA.”
Selank administration caused alterations in the expression of genes involved in neurotransmission, suggesting allosteric modulation of the GABAergic system
“Our results showed that Selank caused a number of alterations in the expression of genes involved in neurotransmission.”

Limitations stated by the authors

The study was conducted in rats, and further research is needed to identify all aspects of the mechanisms of action in different models
“Further research is needed to identify all aspects of the mechanisms of action of Selank and the effects of this peptide on various neurotransmitter systems in different models.”

Source: PubMed 26924987 · DOI 10.3389/fphar.2016.00031 · all study summaries

Reported findings

Significant changes in the expression of 45 genes were observed 1 hour after administration of Selank or GABA

“We found significant changes in the expression of 45 genes 1 h after the administration of the compounds.”

A positive correlation was found between gene expression changes after Selank and GABA administration at 1 hour

“We found positive correlation between the changes in genes expression within 1 h after administration of Selank or GABA.”

Selank administration caused alterations in the expression of genes involved in neurotransmission, suggesting allosteric modulation of the GABAergic system

“Our results showed that Selank caused a number of alterations in the expression of genes involved in neurotransmission.”

Limitations stated by the authors

The study was conducted in rats, and further research is needed to identify all aspects of the mechanisms of action in different models

“Further research is needed to identify all aspects of the mechanisms of action of Selank and the effects of this peptide on various neurotransmitter systems in different models.”