Hexarelin, a Growth Hormone Secretagogue, Improves Lipid Metabolic Aberrations in Nonobese Insulin-Resistant Male MKR Mice.

Animal study examining hexarelin effects in mice

“In this study, the effects of twice daily intraperitoneal injections of hexarelin (200 μg/kg body weight) were examined in nonobese insulin-resistant MKR mice and corresponding wild-type FVB mice for 12 days.”

Nonobese insulin-resistant MKR mice and wild-type FVB mice

“In this study, the effects of twice daily intraperitoneal injections of hexarelin (200 μg/kg body weight) were examined in nonobese insulin-resistant MKR mice and corresponding wild-type FVB mice for 12 days.”

12 days

“In this study, the effects of twice daily intraperitoneal injections of hexarelin (200 μg/kg body weight) were examined in nonobese insulin-resistant MKR mice and corresponding wild-type FVB mice for 12 days.”

Hexarelin improved glucose and insulin intolerance and decreased triglycerides in MKR mice

“Hexarelin treatment significantly improved glucose and insulin intolerance and decreased plasma and liver triglycerides in MKR mice.”

Hexarelin corrected body composition by decreasing fat mass and increasing lean mass

“Moreover, hexarelin treatment corrected the abnormal body composition of MKR mice, as demonstrated by a decrease in fat mass and an increase in lean mass.”

Increased food intake did not change total body weight in treated mice

“Interestingly, although food intake of hexarelin-treated MKR mice was significantly increased, this did not change total body weight.”