Hexarelin · research summary

Modulation of PTEN by hexarelin attenuates coronary artery ligation-induced heart failure in rats.

Turkish journal of medical sciences · 2019. Summary drawn from the study's full text. Each statement is followed by the exact sentence it comes from. This is a research summary, not medical advice.

Study type

Animal study investigating hexarelin effects on coronary artery ligation-induced heart failure in rats
“This study investigated the therapeutic role of hexarelin and the mechanisms underlying its cardioprotective effects against coronary artery ligation (CAL)-induced HF in rats.”

Subjects

Male Sprague-Dawley rats
“A total of 96 male SD rats aged 10–12 weeks weighing between 210 g and 230 g were obtained from the Experimental Animal Center of Harbin Medical University, Harbin, China.”

Sample size

96 rats
“A total of 96 male SD rats aged 10–12 weeks weighing between 210 g and 230 g were obtained from the Experimental Animal Center of Harbin Medical University, Harbin, China.”

Duration

30 days of treatment following 4 weeks of heart failure induction
“All the rats in the four groups were then treated for 30 days.”

Reported findings

Hexarelin improved left ventricular function and ameliorated myocardial remodeling
“The treatment of HF rats with hexarelin signiﬁcantly induced the upregulation of phosphatase and tensin homologue (PTEN) expression and inhibited the phosphorylation of protein kinase B (Akt) and mammalian target of rapamycin (mTOR) to significantly improve LV function, ameliorate myocardial remodeling, and reduce oxidative stress.”
Hexarelin reduced oxidative stress by increasing SOD activity and decreasing MDA levels
“The administration of hexarelin markedly reversed the decrease in the activity of SOD and the increase in MDA levels induced by CAL (P < 0.05).”
Hexarelin attenuated apoptosis and modulated PTEN/Akt/mTOR signaling pathways
“These findings indicate that hexarelin attenuates CAL-induced HF in rats by ameliorating myocardial remodeling, LV dysfunction, and oxidative stress via the upmodulation of PTEN signaling and downregulation of the Akt/mTOR signaling pathway.”

Source: PubMed 31091855 · DOI 10.3906/sag-1812-49 · all study summaries

Reported findings

Hexarelin improved left ventricular function and ameliorated myocardial remodeling

“The treatment of HF rats with hexarelin signiﬁcantly induced the upregulation of phosphatase and tensin homologue (PTEN) expression and inhibited the phosphorylation of protein kinase B (Akt) and mammalian target of rapamycin (mTOR) to significantly improve LV function, ameliorate myocardial remodeling, and reduce oxidative stress.”

Hexarelin reduced oxidative stress by increasing SOD activity and decreasing MDA levels

“The administration of hexarelin markedly reversed the decrease in the activity of SOD and the increase in MDA levels induced by CAL (P < 0.05).”

Hexarelin attenuated apoptosis and modulated PTEN/Akt/mTOR signaling pathways

“These findings indicate that hexarelin attenuates CAL-induced HF in rats by ameliorating myocardial remodeling, LV dysfunction, and oxidative stress via the upmodulation of PTEN signaling and downregulation of the Akt/mTOR signaling pathway.”