Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males.

Narrative review of existing literature on growth hormone secretagogues

“The present review examines the existing literature on the use of GHS and explores their potential complementary role in the management of hypogonadal and eugonadal males with metabolic syndrome or subclinical hypogonadism (SH).”

Hypogonadal and eugonadal males, including those with metabolic syndrome or subclinical hypogonadism

“The present review examines the existing literature on the use of GHS and explores their potential complementary role in the management of hypogonadal and eugonadal males with metabolic syndrome or subclinical hypogonadism (SH).”

Growth hormone secretagogues stimulate endogenous GH and IGF-1 levels without exceeding physiologic norms

“GHS increase serum levels of endogenous GH and IGF-1 in a similar fashion to what is observed with exogenous GH therapy while not exceeding physiologic norms.”

Current clinical data on the efficacy of GHS for hypogonadism is limited

“However, with a lack of large longitudinal studies specifically examining the use of GHS in the management of hypogonadal men, our understanding of their role and any potential long-term risks is limited.”