Ipamorelin · research summary

Attenuation of Visceral and Somatic Nociception by Ghrelin Mimetics.

Journal of experimental pharmacology · 2020. Summary drawn from the study's full text. Each statement is followed by the exact sentence it comes from. This is a research summary, not medical advice.

Study type

Preclinical animal study investigating the efficacy of ghrelin mimetics in a rat model of non-inflammatory visceral and somatic hypersensitivity.
“Here, we investigate the efficacy of peripherally restricted (ipamorelin) and a globally active (HM01) selective ghrelin receptor agonist in an experimental model of non-inflammatory visceral hypersensitivity and somatic mechanical allodynia.”

Subjects

Male Sprague Dawley rats.
“Male Sprague Dawley rats (300–400 g, 76–84 days old on arrival) were purchased from Charles River Laboratories (Wilmington, MA).”

Sample size

A total of 101 rats were used to complete the study.
“A total of 101 rats were used to complete this study.”

Duration

Sensitivity assessments were conducted 60 minutes after the induction of hypersensitivity via acetic acid infusion.
“Colonic sensitivity was assessed 60 min following the infusion of the dilute acetic acid, between 10:00 AM and 2:00 PM.”

Reported findings

Ghrelin mimetics HM01 and ipamorelin significantly attenuated colonic hypersensitivity and somatic allodynia compared to vehicle controls.
“Compared to vehicle controls, ghrelin mimetics HM01 and ipamorelin significantly attenuated colonic hypersensitivity and somatic allodynia.”
The anti-nociceptive effects of the ghrelin mimetics were blocked by the administration of the ghrelin receptor antagonist H0900.
“The anti-nociceptive effects of the ghrelin mimetics were blocked after administration of the ghrelin receptor antagonist H0900.”
Ghrelin receptor-mediated mechanisms are involved in visceral and somatic hypersensitivity in the absence of active colonic inflammation.
“We have shown that ghrelin receptor-mediated mechanisms are involved in visceral and somatic hypersensitivity in the absence of active colonic inflammation.”

Source: PubMed 32801950 · DOI 10.2147/JEP.S249747 · all study summaries

Study type

Preclinical animal study investigating the efficacy of ghrelin mimetics in a rat model of non-inflammatory visceral and somatic hypersensitivity.

“Here, we investigate the efficacy of peripherally restricted (ipamorelin) and a globally active (HM01) selective ghrelin receptor agonist in an experimental model of non-inflammatory visceral hypersensitivity and somatic mechanical allodynia.”

Reported findings

Ghrelin mimetics HM01 and ipamorelin significantly attenuated colonic hypersensitivity and somatic allodynia compared to vehicle controls.

“Compared to vehicle controls, ghrelin mimetics HM01 and ipamorelin significantly attenuated colonic hypersensitivity and somatic allodynia.”

The anti-nociceptive effects of the ghrelin mimetics were blocked by the administration of the ghrelin receptor antagonist H0900.

“The anti-nociceptive effects of the ghrelin mimetics were blocked after administration of the ghrelin receptor antagonist H0900.”

Ghrelin receptor-mediated mechanisms are involved in visceral and somatic hypersensitivity in the absence of active colonic inflammation.

“We have shown that ghrelin receptor-mediated mechanisms are involved in visceral and somatic hypersensitivity in the absence of active colonic inflammation.”