Semax, a Synthetic Regulatory Peptide, Affects Copper-Induced Abeta Aggregation and Amyloid Formation in Artificial Membrane Models.

In vitro biophysical and cell-based study

“Here, we performed a combination of biophysical and biological experiments to test the ability of Semax to modulate fiber formation in both the presence and absence of Cu2+ and model membranes.”

Semax reduces the levels of soluble Aβ oligomers

“Interestingly, the presence of Semax in the Aβ/copper sample was reported to lower the level of all the bands corresponding to Aβ oligomeric species.”

Further in-depth experiments are needed to investigate the effect of Semax on ROS production

“More in-depth experiments should be done especially to investigate the effect of Semax on ROS production, which is known to increase as an effect of Aβ:Cu2+ interaction.”