Peptides Regulating Proliferative Activity and Inflammatory Pathways in the Monocyte/Macrophage THP-1 Cell Line.

In vitro study evaluating the effects of five peptides on human monocytic THP-1 cells and their differentiation into macrophages.

“This study evaluates the effects of five different peptides, the Epitalon® tetrapeptide, the Vilon® dipeptide, the Thymogen® dipeptide, the Thymalin® peptide complex, and the Chonluten® tripeptide, as regulators of inflammatory and proliferative processes in the human monocytic THP-1, which is a human leukemia monocytic cell line capable of differentiating into macrophages by PMA in vitro.”

Three independent experiments were performed for the reported assays.

“Data are represented with bar graphs as the mean ± SD of three independent experiments.”

The peptides inhibited the expression of TNF and pro-inflammatory IL-6 cytokines stimulated by LPS on terminally differentiated THP-1 cells.

“Therefore, all peptides inhibited the expression of TNF and pro-inflammatory IL-6 cytokine stimulated by LPS on terminally differentiated THP-1 cells.”