Insight into Glyproline Peptides' Activity through the Modulation of the Inflammatory and Neurosignaling Genetic Response Following Cerebral Ischemia-Reperfusion.

Preclinical animal study investigating the effects of PGP-containing peptides on gene expression in a rat model of transient middle cerebral artery occlusion.

“Here, using real-time RT-PCR, the effect of other PGP-containing peptides, PGP and Pro-Gly-Pro-Leu (PGPL), on the expression of a number of genes in the IC and NC was studied 24 h after tMCAO.”

A regulatory gene network analysis identified three clusters of signaling pathways reflecting Semax-unlike and Semax-like effects of PGP and PGPL relative to Semax treatment.

“In a network, all the signaling pathways formed three clusters: a Semax-unlike cluster for both the PGP and PGPL peptides, a Semax-unlike cluster for the PGPL but not PGP peptide, and a Semax-like cluster for both the PGP and PGPL peptides (Figure 4).”