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Saturday, October 17, 2026 · Vol. I, No. 42Independent · Canadian · Research-first
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GHK-Cu · research summary
bioRxiv : the preprint server for biology · 2023. Summary drawn from the study's full text. Each statement is followed by the exact sentence it comes from. This is a research summary, not medical advice.
Preclinical animal study testing intranasal GHK-Cu in aging mice
“In order to test this concept, male and female C57BL/6 mice, 20 months of age, were given intranasal GHK-Cu, 15 mg/kg daily, for two months.”
Male and female C57BL/6 mice aged 20 months
“C57BL/6Jnia male and female mice, 20 months of age, were obtained from the National Institute on Aging Aged Rodent Colony, contracted by Charles River, Inc.”
8 weeks (two months) of daily treatment
“Mice were given 15 mg/kg in 20 ɥL saline daily between 7 AM and 10 AM over an 8-week period.”
Mice treated with intranasal GHK-Cu showed enhanced cognitive performance in spatial memory and learning navigation tasks compared to saline-treated mice.
“Results showed that mice treated with intranasal GHK-Cu had an enhanced level of cognitive performance in spatial memory and learning navigation tasks, and expressed decreased neuroinflammatory and axonal damage markers compared to mice treated with intranasal saline.”
The effects of the treatment were sex-dependent, with males showing earlier cognitive improvements than females.
“Interestingly, after 4 weeks of treatment, only males experienced higher alternation percentages indicating females required a longer period of time to respond to treatment.”
Source: PubMed 38014118 · DOI 10.1101/2023.11.16.567423 · all study summaries