GHRP-6 · research summary

Ghrelin misbalance affects mice embryo implantation and pregnancy success by uterine immune dysregulation and nitrosative stress.

Frontiers in endocrinology · 2023. Summary drawn from the study's full text. Each statement is followed by the exact sentence it comes from. This is a research summary, not medical advice.

Study type

In vivo animal study using a mouse model of gestational ghrelin misbalance
“Using our animal model of gestational Ghrl imbalance during the peri-implantation period we analyzed the effects on embryo implantation, uterine NOS activity/NO synthesis and uterine inflammatory/immune profile.”

Reported findings

Antagonist treatment altered the uterine immune profile by increasing pro-inflammatory cytokines (IL-6, IL-17, MMP9), decreasing IL-10, and increasing NK and dendritic cells while decreasing T cells
“(D-Lys3)GHRP-6-treatment increased also the expression of the inflammatory cytokines IL-6, IL-17 and MMP9, and decreased that of IL-10 (anti-inflammatory). Moreover, Ant-treatment increased also the NK cells population and that of CD11b+ dendritic cells; and decreased T cells percentages.”

Source: PubMed 38107518 · DOI 10.3389/fendo.2023.1288779 · all study summaries