Ghrelin Improves Glucolipotoxicity-Induced Pancreatic β-Cellular Dysfunction and Apoptosis by Inhibiting Endoplasmic Reticulum Stress-Induced IRE1/JNK Pathway.

In vitro study using mouse insulinoma cells

“Mouse insulinoma β-cell, NIT-1 cells, were stimulated with high fat and high glucose to induce glucolipid toxicity.”

Mouse insulinoma β-cells (NIT-1)

“Mouse insulinoma β-cell, NIT-1 cells, were stimulated with high fat and high glucose to induce glucolipid toxicity.”

Ghrelin treatment improved cell viability and inhibited apoptosis in glucolipotoxicity-induced NIT-1 cells

“Ghrelin treatment improved cell viability while inhibiting cell glucolipotoxicity-induced NIT-1 cell apoptosis.”

Ghrelin promoted insulin synthesis and secretion in NIT-1 cells

“Ghrelin can promote the synthesis and secretion of insulin in NIT-1 cells.”

Ghrelin attenuated endoplasmic reticulum stress and inhibited the IRE1/JNK signaling pathway

“Mechanistically, ghrelin attenuates ERS and inhibits the IRE1/JNK signaling pathway in NIT-1 cells induced by glucolipotoxicity.”