CROI 2024: Neuropsychiatric Complications in People With HIV.

Review of findings from the 2024 Conference on Retroviruses and Opportunistic Infections

“This review summarizes these and other new findings and highlights new research directions for the neuro-HIV field.”

People with HIV and other infections

“The 2024 Conference on Retroviruses and Opportunistic Infections featured new and impactful findings about neuropsychiatric complications in people with HIV and other infections.”

Active HIV RNA transcription occurs in cells from cerebrospinal fluid and the brain during virally suppressive antiretroviral therapy

“Also included were new evidence of active HIV RNA transcription in cells from cerebrospinal fluid and the brain during virally suppressive antiretroviral therapy”

Links exist between neuropsychiatric complications or brain imaging findings in people with HIV and carotid artery inflammation, Alzheimer's disease genetic risk, social determinants of health, and epigenetic aging

“as well as links between neuropsychiatric complications or brain imaging findings in people with HIV and a) carotid artery inflammation and cerebrovascular disease, b) Alzheimer's disease genetic risk, c) social determinants of health, including exposure to pollution, and d) epigenetic aging.”

New therapeutic findings were presented regarding the cerebrospinal fluid inhibitory quotient, the effects of polypharmacy, and clinical trials of tesamorelin and telmisartan

“New therapeutic findings were presented on the cerebrospinal fluid inhibitory quotient, the effects of polypharmacy, and clinical trials of tesamorelin and telmisartan.”