ACTH-like Peptides Compensate Rat Brain Gene Expression Profile Disrupted by Ischemia a Day After Experimental Stroke.

Preclinical animal study using RNA-Seq to analyze transcriptome changes in rat frontal cortex after ischemic stroke and peptide administration.

“The aim of the current study was a comparative analysis of the effects of ACTH(6–9)PGP and Semax on the transcriptome of the frontal cortex region of rats, including viable cells, the perifocal zone and ischemic area, 24 h after tMCAO.”

Analysis performed at 24 hours after the onset of occlusion or sham operation.

“The study rats were decapitated at 24 h after the beginning of occlusion/sham operation procedures.”

Peptide administration was associated with upregulation of genes related to neurogenesis, angiogenesis, protein kinases, and growth factors.

“Besides, neurogenesis-, angiogenesis-, protein kinase- and growth factor-related DEGs were revealed under peptides action.”