Ghrelin suppresses water intake with a different physiological significance from atrial natriuretic peptide in conscious seawater-acclimated eels.

Experimental study on water intake in conscious seawater-acclimated eels

“In this study, the effect of ghrelin on water intake was comprehensively addressed using conscious seawater-acclimated eels as an experimental model for water drinking behaviour.”

Conscious seawater-acclimated eels

“In this study, the effect of ghrelin on water intake was comprehensively addressed using conscious seawater-acclimated eels as an experimental model for water drinking behaviour.”

Intra-cerebroventricular injection of ghrelin decreased the drinking rate without affecting arterial pressure

“Similarly, intra-cerebroventricular injection of ghrelin also decreased the drinking rate without affecting arterial pressure.”

The inhibitory action of ghrelin was not blocked by pre-treatment with a ghrelin receptor antagonist

“The inhibitory action was not blocked by pre-treatment with a ghrelin receptor antagonist ([D-Lys3] GHRP-6); consistently, the agonist form (GHRP-6) injected intra-arterially did not show any inhibitory effect of ghrelin when injected peripherally.”