Topically applied GHK as an anti-wrinkle peptide: Advantages, problems and prospective.

Review

“This review aims to highlight whether GHK is sufficiently effective on wrinkle prevention/reduction.”

There is a lack of clinical studies for GHK-Cu and Pal-GHK

“Although GHK-Cu and Pal-GHK have been of interest as effective peptides to be incorporated in the anti-wrinkle products, there is a surprising absence of clinical studies using them.”

Insufficient published information on skin permeability, effectiveness, and physicochemical properties

“Although GHK-Cu and Pal-GHK are widely used in anti-wrinkle products available on the cosmetic market, the published information on their skin permeability, effectiveness, physicochemical properties and so on is insufficient.”