Protective Effects of BPC 157 on Liver, Kidney, and Lung Distant Organ Damage in Rats with Experimental Lower-Extremity Ischemia-Reperfusion Injury.

Experimental animal study evaluating the protective effects of BPC-157 on remote organ damage in a rat model of skeletal muscle ischemia-reperfusion injury.

“This study evaluates the protective effects of BPC-157 on remote organ damage, including the kidneys, liver, and lungs, in a rat model of skeletal muscle I/R injury.”

Male Wistar albino rats.

“A total of 24 male Wistar albino rats were randomly divided into four groups: sham (S), BPC-157(B), lower extremity I/R(IR) and lower extremity I/R+BPC-157(I/RB).”

24 rats divided into four groups of 6 each.

“A total of 24 rats were randomly divided into four experimental groups (n = 6 per group): control, group B, IR, and IR-BPC157.”

45 minutes of ischemia followed by 2 hours of reperfusion.

“Some 45 min of ischemia of lower extremity was followed by 2 h of reperfusion of limbs.”

BPC-157 demonstrated a significant protective effect against distant organ damage in the liver, kidneys, and lungs following lower extremity ischemia-reperfusion injury.

“The findings of this study demonstrate that BPC-157 exerts a significant protective effect against distant organ damage in the liver, kidneys, and lungs following lower extremity ischemia–reperfusion injury in rats.”