Unveiling lymphocyte dynamics: Navigating postoperative immune landscapes in gastric cancer patients undergoing laparoscopic D2 gastrectomy.

Retrospective analysis of clinicopathological data

“We retrospectively analyzed clinicopathological data from 169 gastric cancer patients, focusing on perioperative lymphocyte subset variations.”

Gastric cancer patients undergoing laparoscopic D2 gastrectomy

“This study investigates the dynamics of peripheral lymphocyte subsets in gastric cancer patients post-laparoscopic D2 gastrectomy.”

169 patients

“We retrospectively included 169 gastric cancer patients who underwent laparoscopic gastrectomy between April 2022 and July 2024.”

Observation up to postoperative day 7

“By postoperative day 7, we observed median decreases in T cells, B cells, NK cells, and memory T cells of −26.1%, −30.8%, −44.8%, and −2.3%, respectively.”

Thymosin alpha 1 (Tα1) therapy identified as a protective factor reducing T and B cell decline

“Thymosin alpha 1 (Tα1) treatment proved to be a protective factor, significantly reducing the decline in T and B cell counts (p = 0.05).”

Higher Interleukin-1β levels and longer operation times identified as independent predictors of T cell reduction

“Multivariate analysis identified higher Interleukin-1β levels (HR = 3.66, p = 0.01), longer operation times (HR = 2.98, p = 0.02), and Tα1 therapy (HR = 0.15, p = 0.01) as independent predictors of T cell reduction.”