Aza-Isotryptophan: Synthesis, Pictet-Spengler Chemistry, Incorporation and Conformational Analysis in Peptides, and Activity in Modulators of the Cluster of Differentiation-36 Receptor.

Synthesis, conformational analysis, and receptor binding activity study

“Aza-Isotryptophan: Synthesis, Pictet-Spengler Chemistry, Incorporation and Conformational Analysis in Peptides, and Activity in Modulators of the Cluster of Differentiation-36 Receptor.”

Model peptides of the Ala-azaItr-d-Phe triad and azaItr analogs of growth hormone-releasing peptide 6

“β-Turn geometry was characterized in model peptides of the Ala-azaItr-d-Phe triad by X-ray and NMR analyses.”

β-Turn geometry was characterized in model peptides using X-ray and NMR analyses

“β-Turn geometry was characterized in model peptides of the Ala-azaItr-d-Phe triad by X-ray and NMR analyses.”

azaItr analogs of GHRP-6 demonstrated promising CD36 receptor binding affinity

“Moreover, azaItr analogs of growth hormone-releasing peptide 6 (GHRP-6) demonstrated a promising cluster of differentiation-36 receptor (CD36) binding affinity and modulatory effect on the inflammatory response induced by the activated complex composed of the latter coreceptor in the Toll-like receptor-2/6 heterodimer.”