Pyoderma Gangrenosum Secondary to Melanotan.

Case report

“This is the first case report of PG secondary to melanotan injections described within the literature.”

A 65-year-old woman with no significant past medical history

“A 65-year-old woman presented to the dermatology clinic with an ulcerated lesion and three areas of impending ulceration on her lower abdomen.”

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“A 65-year-old woman reported utilising Melanotan and subsequently developing ulcerated wounds at the injection sites on her abdomen.”

Several months of treatment

“The wounds healed with classic cribriform scars after several months of treatment.”

Pyoderma gangrenosum developed at melanotan injection sites

“In our patient, PG developed at sites in which melanotan was injected.”

The condition was diagnosed clinically after lack of response to antibiotics and negative bacteriology

“A diagnosis of PG was obtained due to the wounds’ appearance, progression rate, lack of response to multiple courses of antibiotics, and negative bacteriology, including Panton-Valentine leukocidin Staphylococcus aureus.”

The lesions healed with cribriform scars following topical and systemic steroid therapy

“The PG healed with a classic cribriform scar after several months of topical treatment (Figure 4).”

It is difficult to differentiate whether the melanotan constituents or the trauma of the injection caused the condition

“It is difficult to differentiate whether it was the constituents of the melanotan itself or the trauma of the injection (pathergy) that caused PG in our patient.”