Tracheocutaneous Fistula Resolved by Pentadecapeptide BPC 157 Therapy Through the NO-System-Triple NO-Agent Approach in Rats.

7-day experimental animal study in rats with surgically induced tracheocutaneous fistulas

“This 7-day rat tracheocutaneous fistula study considered the not-studied issues of tracheocutaneous fistula course, wound healing, and fistula in the NO-system relations.”

Male albino Wistar rats

“The study was conducted with appropriately randomized male albino Wistar rats, 12–16 weeks of age, 280 g in body weight, who were self-breeded in the Department of Pharmacology, Faculty of Medicine, Zagreb, Croatia.”

BPC 157 reversed the worsening effects of L-NAME and the immobilization effects of combined L-NAME and L-arginine, restoring full healing.

“Finally, when combined, BPC 157 therapy upgrades L-arginine amelioration, abolishes L-NAME-induced worsening, and restores full healing after NO immobilization (L-NAME+L-arginine).”