Melanotan II · research summary

Changes in Oral Mucosa Associated with Melanotan II Injections: A Case Report.

Life (Basel, Switzerland) · 2026. Summary drawn from the study's full text. Each statement is followed by the exact sentence it comes from. This is a research summary, not medical advice.

Study type

Case report
“This case report presents a three-month follow-up of a patient who self-administered Melanotan II injections over a period of 64 days with the goal of achieving a deeper tanning effect.”

Subjects

42-year-old Caucasian male
“A 42-year-old Caucasian male presented to the dental office for a routine dental examination.”

Sample size

1
“This case report presents a three-month follow-up of a patient who self-administered Melanotan II injections over a period of 64 days with the goal of achieving a deeper tanning effect.”

Duration

64 days of administration followed by a 3-month follow-up period
“He self-administered the peptide subcutaneously in the lower abdomen at a dose of 400 micrograms every other day over a 64-day period, for a total of 32 injections and a cumulative dose of 12.8 mg.”

Reported findings

Brown pigmentation was observed on the attached gingiva and buccal mucosa during the administration period.
“Intraoral examination revealed brown pigmentation of the attached gingiva in both the maxillary and mandibular arches.”
Buccal mucosal pigmentation nearly disappeared one month after discontinuation.
“At the one-month follow-up after discontinuation of the injections, the buccal mucosal pigmentation had nearly disappeared.”
Gingival pigmentation persisted with reduced intensity at the three-month follow-up.
“However, at the three-month follow-up, gingival pigmentation persisted, though with visibly reduced intensity.”

Limitations stated by the authors

Lack of published data on the timeline for resolution of oral pigmentation associated with Melanotan II use
“To date, there is a lack of published data specifically addressing the timeline for resolution of oral pigmentation associated with Melanotan II use, making this case a valuable contribution to the limited existing literature on the subject.”

Source: PubMed 41752902 · DOI 10.3390/life16020265 · all study summaries

Reported findings

Brown pigmentation was observed on the attached gingiva and buccal mucosa during the administration period.

“Intraoral examination revealed brown pigmentation of the attached gingiva in both the maxillary and mandibular arches.”

Buccal mucosal pigmentation nearly disappeared one month after discontinuation.

“At the one-month follow-up after discontinuation of the injections, the buccal mucosal pigmentation had nearly disappeared.”

Gingival pigmentation persisted with reduced intensity at the three-month follow-up.

“However, at the three-month follow-up, gingival pigmentation persisted, though with visibly reduced intensity.”

Limitations stated by the authors

Lack of published data on the timeline for resolution of oral pigmentation associated with Melanotan II use

“To date, there is a lack of published data specifically addressing the timeline for resolution of oral pigmentation associated with Melanotan II use, making this case a valuable contribution to the limited existing literature on the subject.”