MOTS-c · research summary

Are serum MOTS-c levels and MOTS-c m.1382A>C polymorphism related to polycystic ovary syndrome?

Archives of endocrinology and metabolism · 2026. Summary drawn from the study's full text. Each statement is followed by the exact sentence it comes from. This is a research summary, not medical advice.

Study type

Case-control study
“A case-control study involving adolescent girls diagnosed with PCOS and a control group of adolescents with regular menstrual cycles was conducted.”

Subjects

Adolescent girls aged 12-18 with PCOS and healthy controls with regular menstrual cycles
“Adolescents aged 12-18 diagnosed with PCOS were recruited based on irregular menstrual cycles and clinical/biochemical hyperandrogenism, excluding other conditions.”

Sample size

121 adolescents with PCOS and 125 healthy controls
“The study included 121 adolescents with PCOS and 125 healthy controls.”

Reported findings

Serum MOTS-c levels were higher in the PCOS group but the difference was not statistically significant
“The mean serum MOTS-c levels in the PCOS group were higher than in the control group; however, this difference did not reach statistical significance (p = 0.059).”
No significant association was found between MOTS-c levels and anthropometric or metabolic parameters in the PCOS group
“There was no significant association between MOTS-c levels and anthropometric or metabolic parameters within the PCOS group (p > 0.05).”
All participants had the wild-type genotype for the m.1382A>C polymorphism
“All participants had the wild-type (A/A) genotype for the m.1382A>C polymorphism.”

Limitations stated by the authors

Absence of metabolic and hormonal profiling in the control group and evaluation of only a single polymorphism
“The main limitations of this study include the absence of metabolic and hormonal profiling in the control group and the evaluation of only a single polymorphism (rs111033358, m.1382A>C) among the MOTS-c gene variants.”

Source: PubMed 41945630 · DOI 10.20945/2359-4292-2026-0031 · all study summaries

Reported findings

Serum MOTS-c levels were higher in the PCOS group but the difference was not statistically significant

“The mean serum MOTS-c levels in the PCOS group were higher than in the control group; however, this difference did not reach statistical significance (p = 0.059).”

No significant association was found between MOTS-c levels and anthropometric or metabolic parameters in the PCOS group

“There was no significant association between MOTS-c levels and anthropometric or metabolic parameters within the PCOS group (p > 0.05).”

All participants had the wild-type genotype for the m.1382A>C polymorphism

“All participants had the wild-type (A/A) genotype for the m.1382A>C polymorphism.”

Limitations stated by the authors

Absence of metabolic and hormonal profiling in the control group and evaluation of only a single polymorphism

“The main limitations of this study include the absence of metabolic and hormonal profiling in the control group and the evaluation of only a single polymorphism (rs111033358, m.1382A>C) among the MOTS-c gene variants.”