MOTS-c · research summary

The Association Between Serum MOTS-c Levels and Myocardial Ischemia-Reperfusion Injury in Patients with Acute Myocardial Infarction: A Cross-Sectional Study.

Biomedicines · 2026. Summary drawn from the study's full text. Each statement is followed by the exact sentence it comes from. This is a research summary, not medical advice.

Study type

Single-center cross-sectional case-control study
“This was a single-center cross-sectional case–control study.”

Subjects

Patients with acute myocardial infarction undergoing percutaneous coronary intervention
“A total of 72 patients, who were admitted with AMI in Department of Cardiology, The Third Affiliated Hospital of Chongqing Medical University and underwent PCI from January 2024 to June 2025, were selected.”

Sample size

72 patients (34 in MIRI group, 38 in non-MIRI group)
“Seventy-two AMI patients undergoing PCI were enrolled and divided into MIRI (n = 34) and non-MIRI (n = 38) groups.”

Duration

Enrollment period from January 2024 to June 2025
“A total of 72 patients, who were admitted with AMI in Department of Cardiology, The Third Affiliated Hospital of Chongqing Medical University and underwent PCI from January 2024 to June 2025, were selected.”

Reported findings

Postoperative peripheral serum MOTS-c levels were significantly lower in the MIRI group compared to the non-MIRI group.
“Postoperative peripheral serum MOTS-c levels were significantly lower in the MIRI group than in the non-MIRI group (p < 0.05), while preoperative peripheral and intracoronary MOTS-c levels showed no significant differences between groups.”
Multivariate logistic regression identified postoperative peripheral MOTS-c levels and preoperative TIMI grade ≥ 1 as independent protective factors for MIRI, while serum creatinine was an independent risk factor.
“Multivariate logistic regression identified postoperative peripheral MOTS-c levels (OR = 0.986, 95%CI: 0.976–0.996) and preoperative TIMI grade ≥ 1 (OR = 0.036, 95%CI: 0.004–0.309) as independent protective factors for MIRI, whereas serum creatinine was identified as an independent risk factor.”
ROC analysis showed that postoperative peripheral MOTS-c levels predicted MIRI with an area under the curve of 0.648.
“ROC analysis demonstrated that postoperative peripheral MOTS-c levels predicted MIRI with an area under the curve of 0.648.”

Limitations stated by the authors

Single-center design, limited sample size, lack of systematic TIMI myocardial blush grade recording, and modest predictive performance due to single time-point sampling.
“First, as a single-center cross-sectional study, its design can reveal associations but cannot establish causality. Second, the limited sample size may affect statistical power. Third, TIMI myocardial blush grade (TMB), an important indicator of microcirculatory perfusion, was not systematically recorded in this study.”

Source: PubMed 42072458 · DOI 10.3390/biomedicines14040918 · all study summaries

Reported findings

Postoperative peripheral serum MOTS-c levels were significantly lower in the MIRI group compared to the non-MIRI group.

“Postoperative peripheral serum MOTS-c levels were significantly lower in the MIRI group than in the non-MIRI group (p < 0.05), while preoperative peripheral and intracoronary MOTS-c levels showed no significant differences between groups.”

Multivariate logistic regression identified postoperative peripheral MOTS-c levels and preoperative TIMI grade ≥ 1 as independent protective factors for MIRI, while serum creatinine was an independent risk factor.

“Multivariate logistic regression identified postoperative peripheral MOTS-c levels (OR = 0.986, 95%CI: 0.976–0.996) and preoperative TIMI grade ≥ 1 (OR = 0.036, 95%CI: 0.004–0.309) as independent protective factors for MIRI, whereas serum creatinine was identified as an independent risk factor.”

ROC analysis showed that postoperative peripheral MOTS-c levels predicted MIRI with an area under the curve of 0.648.

“ROC analysis demonstrated that postoperative peripheral MOTS-c levels predicted MIRI with an area under the curve of 0.648.”

Limitations stated by the authors

Single-center design, limited sample size, lack of systematic TIMI myocardial blush grade recording, and modest predictive performance due to single time-point sampling.

“First, as a single-center cross-sectional study, its design can reveal associations but cannot establish causality. Second, the limited sample size may affect statistical power. Third, TIMI myocardial blush grade (TMB), an important indicator of microcirculatory perfusion, was not systematically recorded in this study.”