Endothelium-Dependent Nitric Oxide-Mediated Vasorelaxant Effects of BPC 157 in Human Internal Mammary Artery.

Ex vivo functional study on human arterial tissue

“This study investigated the effects of BPC 157 on vascular tone in human internal mammary artery (IMA) rings and evaluated the contribution of endothelial NO signaling.”

Human internal mammary artery (IMA) rings obtained from patients undergoing elective coronary artery bypass graft surgery

“Residual IMA segments obtained from elective coronary artery bypass graft surgeries (n = 12) were dissected into endothelium-intact and endothelium-denuded rings.”

BPC 157 produced a concentration-dependent reduction in phenylephrine-induced contraction, with significantly greater relaxation in endothelium-intact rings compared to denuded rings.

“BPC 157 produced a concentration-dependent reduction in PheE-induced contraction in both groups, with significantly greater relaxation in endothelium-intact rings (p < 0.05).”

Endothelial integrity enhanced maximal vasorelaxation (Emax), an advantage that was largely abolished after NOS inhibition.

“Emax analysis demonstrated that endothelial integrity markedly enhanced maximal vasorelaxation, whereas this advantage was largely abolished after NOS inhibition.”