MOTS-c · research summary

MOTS-c, a mitochondrial-derived peptide, ameliorates lysosomal membrane permeability and improves survival of soft tissue transplantation.

Autophagy · 2026. Summary drawn from the study's full text. Each statement is followed by the exact sentence it comes from. This is a research summary, not medical advice.

Study type

Investigation of MOTS-c protective effects and mechanisms in ischemic flaps using RNA sequencing, imaging, and molecular assays
“This study investigated the protective effects and underlying mechanisms of MOTS-c in ischemic flaps.”

Subjects

Ischemic flaps and endothelial cells
“MOTS-c reduced endothelial pyroptosis, enhanced autophagy, and attenuated LMP in ischemic flaps.”

Reported findings

MOTS-c treatment improved blood flow perfusion in ischemic flaps
“Tissue clearing, laser speckle contrast imaging and Doppler analyses revealed improved blood flow perfusion following MOTS-c treatment.”
MOTS-c reduced endothelial pyroptosis, enhanced autophagy, and attenuated lysosomal membrane permeabilization
“MOTS-c reduced endothelial pyroptosis, enhanced autophagy, and attenuated LMP in ischemic flaps.”
MOTS-c inhibited PLA2G4A via the MAPK1-MAPK3-NFKB signaling cascade to reduce LMP and enhance flap survival
“Furthermore, MOTS-c inhibited PLA2G4A via the MAPK1-MAPK3-NFKB signaling cascade, thereby reducing LMP and enhancing flap survival.”

Source: PubMed 42153537 · DOI 10.1080/15548627.2026.2677180 · all study summaries