Maternal-Neonatal Metabolic Continuity and Early Postnatal HPG Axis Activity in Healthy Term Neonates.

Prospective evaluation of associations between maternal metabolic markers and neonatal reproductive hormone activity

“Forty healthy term neonates (20 males) were prospectively evaluated.”

Forty healthy term neonates and their mothers

“Forty healthy term neonates (20 males) were prospectively evaluated.”

40 neonates

“Forty healthy term neonates (20 males) were prospectively evaluated.”

Blood samples collected at delivery and within the first 24 hours after birth

“Maternal venous blood samples were collected at delivery, and neonatal blood samples were obtained within the first 24 h after birth.”

Maternal leptin was positively associated with neonatal leptin concentrations

“Maternal leptin was positively associated with neonatal leptin concentrations (r = 0.52, p = 0.001; adjusted β = 0.47, p = 0.001), supporting maternal–neonatal metabolic continuity.”

Maternal leptin was not significantly associated with neonatal LH concentrations

“However, maternal leptin was not significantly associated with neonatal LH concentrations (β = 0.00009, p = 0.347).”

Sex was the strongest independent predictor of neonatal LH levels

“Sex remained the strongest independent predictor of neonatal LH levels (β = 1.21, p = 0.011).”

Most exploratory associations did not remain statistically significant after FDR correction and larger longitudinal studies are required

“Most exploratory associations did not remain statistically significant after FDR correction.”