MOTS-c · research summary

Mitochondria-derived peptide hydrogel augments mitochondrial transplantation for promoting cardiac repair via macrophage metabolic reprogramming.

Bioactive materials · 2027. Summary drawn from the study's full text. Each statement is followed by the exact sentence it comes from. This is a research summary, not medical advice.

Study type

Preclinical study involving in vitro cell assays and in vivo rat myocardial infarction model
“In a rat MI model, MQgel@Mito reduces M1 macrophage infiltration and cardiomyocyte damage by delivering viable mitochondria, thereby improving cardiac function and limiting pathological remodeling.”

Subjects

Sprague Dawley rats and bone marrow-derived macrophages (BMDMs)
“We isolated donor mitochondria from the skeletal muscles of Sprague Dawley rats.”

Sample size

n = 5 for in vivo echocardiography and histology; n = 3 for most in vitro assays
“Echocardiographic assessment was performed on day 7 and day 28 post-MI to evaluate cardiac function in rats (Fig. 7B).”

Duration

28 days post-myocardial infarction
“Echocardiographic assessment was performed on day 7 and day 28 post-MI to evaluate cardiac function in rats (Fig. 7B).”

Reported findings

MQgel extended the survival of isolated mitochondria and maintained metabolic enzyme activity for at least 8 hours
“It has been observed that MQgel significantly extends the survival of isolated mitochondria and maintains metabolic enzyme activity for at least 8 h.”
MQgel@Mito enhanced mitochondrial internalization by macrophages via an AMPK-dependent mechanism and suppressed pro-inflammatory glycolysis
“More importantly, MQgel not only shields donor mitochondria from oxidative stress and calcium overload, but also enhances mitochondrial internalization by macrophages through an adenosine 5′-monophosphate-activated protein kinase (AMPK)-dependent mechanism.”
MQgel@Mito improved cardiac function and limited pathological remodeling in a rat MI model
“In a rat MI model, MQgel@Mito reduces M1 macrophage infiltration and cardiomyocyte damage by delivering viable mitochondria, thereby improving cardiac function and limiting pathological remodeling.”

Limitations stated by the authors

The text mentions limitations exist but the specific details are cut off in the provided text
“Despite promising results, several limitations exist in the current study.”

Source: PubMed 42633281 · DOI 10.1016/j.bioactmat.2026.06.010 · all study summaries

Reported findings

MQgel extended the survival of isolated mitochondria and maintained metabolic enzyme activity for at least 8 hours

“It has been observed that MQgel significantly extends the survival of isolated mitochondria and maintains metabolic enzyme activity for at least 8 h.”

MQgel@Mito enhanced mitochondrial internalization by macrophages via an AMPK-dependent mechanism and suppressed pro-inflammatory glycolysis

“More importantly, MQgel not only shields donor mitochondria from oxidative stress and calcium overload, but also enhances mitochondrial internalization by macrophages through an adenosine 5′-monophosphate-activated protein kinase (AMPK)-dependent mechanism.”

MQgel@Mito improved cardiac function and limited pathological remodeling in a rat MI model

“In a rat MI model, MQgel@Mito reduces M1 macrophage infiltration and cardiomyocyte damage by delivering viable mitochondria, thereby improving cardiac function and limiting pathological remodeling.”