Kisspeptin · research summary

Emerging peptide and neuroendocrine strategies for TRT-induced reproductive suppression and functional male hypogonadism: a narrative review.

Frontiers in reproductive health · 2026. Summary drawn from the study's full text. Each statement is followed by the exact sentence it comes from. This is a research summary, not medical advice.

Study type

Narrative, non-systematic review
“This study was conducted as a narrative, non-systematic review.”

Subjects

Literature on peptide and neuroendocrine strategies for male reproductive health
“A structured literature search was conducted to identify experimental, translational, and clinical studies investigating reproductive peptides and related neuroendocrine pathways.”

Sample size

39 references selected for inclusion
“Following assessment for scientific relevance, clinical significance, and contribution to the study objectives, 39 references were selected for inclusion in the final evidence synthesis.”

Duration

Literature search last updated in July 2026
“The literature search was last updated in July 2026.”

Reported findings

Peptide-based therapies may support endogenous hormonal signaling through targeted activation of the HPT axis
“Current evidence suggests that peptide-based therapies may support endogenous hormonal signaling through targeted activation of the HPT axis.”
Direct evidence for restoration of spermatogenesis or fertility following TRT-induced suppression is limited
“However, direct evidence demonstrating restoration of spermatogenesis or fertility following TRT-induced suppression remains limited, and important questions regarding long-term efficacy, safety, treatment protocols, and patient selection remain unresolved.”
Kisspeptin has the most extensive human clinical evidence among peptide candidates
“Among currently available peptide candidates, kisspeptin currently has the most extensive human clinical evidence among peptide-based therapeutic candidates.”

Limitations stated by the authors

Limited to early-phase investigations with small sample sizes and lack of large randomized trials
“Additional limitations include small sample sizes, heterogeneous study populations, variable dosing regimens, and limited long-term follow-up.”

Source: PubMed 42666625 · DOI 10.3389/frph.2026.1914709 · all study summaries

Reported findings

Peptide-based therapies may support endogenous hormonal signaling through targeted activation of the HPT axis

“Current evidence suggests that peptide-based therapies may support endogenous hormonal signaling through targeted activation of the HPT axis.”

Direct evidence for restoration of spermatogenesis or fertility following TRT-induced suppression is limited

“However, direct evidence demonstrating restoration of spermatogenesis or fertility following TRT-induced suppression remains limited, and important questions regarding long-term efficacy, safety, treatment protocols, and patient selection remain unresolved.”

Kisspeptin has the most extensive human clinical evidence among peptide candidates

“Among currently available peptide candidates, kisspeptin currently has the most extensive human clinical evidence among peptide-based therapeutic candidates.”