GHRP-6 · research summary

Ghrelin attenuates hypoxia-induced mitochondrial oxidative stress damage in HTR-8/SVneo trophoblasts.

Tissue & cell · 2026. Summary drawn from the study's abstract. Each statement is followed by the exact sentence it comes from. This is a research summary, not medical advice.

Study type

In vitro study using HTR-8/SVneo trophoblast cells
“HTR-8/SVneo cells were divided into 8 groups: normoxia, normoxia + 1000 nmol/L D-Lys3-GHRP-6, hypoxia, hypoxia + 1000 nmol/L D-Lys3-GHRP-6, hypoxia + 1, 10, 100, 1000 nmol/L Ghrelin.”

Subjects

HTR-8/SVneo trophoblast cells
“HTR-8/SVneo cells were divided into 8 groups: normoxia, normoxia + 1000 nmol/L D-Lys3-GHRP-6, hypoxia, hypoxia + 1000 nmol/L D-Lys3-GHRP-6, hypoxia + 1, 10, 100, 1000 nmol/L Ghrelin.”

Reported findings

Hypoxia induced mitochondrial swelling, cristae rupture, ROS accumulation, increased MDA, reduced antioxidant enzyme activities and enhanced apoptosis.
“Hypoxia induced mitochondrial swelling, cristae rupture, ROS accumulation, increased MDA, reduced antioxidant enzyme activities and enhanced apoptosis.”
TGFB2 was identified as a key target upregulated by hypoxia and downregulated by Ghrelin, and its knockdown mimicked Ghrelin-mediated protection.
“Bioinformatics and Western blotting identified TGFB2 as a key target upregulated by hypoxia and downregulated by Ghrelin.”

Source: PubMed 42753464 · DOI 10.1016/j.tice.2026.103950 · all study summaries