LL-37 · research summary

Neurogenic Rosacea and Facial Dysesthesia: Neurovascular-Immune Mechanisms and Translational Therapeutic Perspectives.

Medicina (Kaunas, Lithuania) · 2026. Summary drawn from the study's full text. Each statement is followed by the exact sentence it comes from. This is a research summary, not medical advice.

Study type

Narrative review
“This narrative review evaluates its clinical features, differential diagnosis, proposed mechanisms, and reported therapeutic approaches while distinguishing direct human evidence from indirect and experimental findings.”

Subjects

Patients with rosacea, specifically those with a sensory-weighted presentation (neurogenic rosacea), and experimental models
“Neurogenic rosacea is a clinically useful, but not yet standardized, sensory-weighted presentation within the rosacea spectrum.”

Reported findings

Direct evidence specific to neurogenic rosacea is limited to small observational series and case reports, with no validated diagnostic criteria or phenotype-specific treatment algorithms existing.
“Direct evidence specific to neurogenic rosacea is limited mainly to small observational series and case reports.”
Human rosacea studies support neurovascular involvement, but many proposed links involving TRP channels, proteases, LL-37–MRGPRX2, and mast cells remain indirect or experimental.
“Human rosacea studies support neurovascular involvement, whereas many TRP-channel, protease, LL-37–MRGPRX2, and mast cell links remain indirect or experimental.”
Neurogenic rosacea is best regarded as a clinically useful but not yet standardized sensory-weighted presentation within the rosacea spectrum, rather than an independent phenotype.
“Neurogenic rosacea is best regarded as a clinically useful but not yet standardized sensory-weighted presentation within the rosacea spectrum, as current evidence does not establish it as an independent phenotype.”

Limitations stated by the authors

The review is limited by its narrative design, heterogeneity of terminology, restriction to English-language publications, and reliance on a single author for study selection and assessment.
“This review is limited by its narrative design and heterogeneity of terminology.”

Source: PubMed 42796296 · DOI 10.3390/medicina62091689 · all study summaries

Reported findings

Direct evidence specific to neurogenic rosacea is limited to small observational series and case reports, with no validated diagnostic criteria or phenotype-specific treatment algorithms existing.

“Direct evidence specific to neurogenic rosacea is limited mainly to small observational series and case reports.”

Human rosacea studies support neurovascular involvement, but many proposed links involving TRP channels, proteases, LL-37–MRGPRX2, and mast cells remain indirect or experimental.

“Human rosacea studies support neurovascular involvement, whereas many TRP-channel, protease, LL-37–MRGPRX2, and mast cell links remain indirect or experimental.”

Neurogenic rosacea is best regarded as a clinically useful but not yet standardized sensory-weighted presentation within the rosacea spectrum, rather than an independent phenotype.

“Neurogenic rosacea is best regarded as a clinically useful but not yet standardized sensory-weighted presentation within the rosacea spectrum, as current evidence does not establish it as an independent phenotype.”