Oxytocin · research summary

Carbetocin versus oxytocin during elective cesarean delivery: A randomized double-blind trial.

Pakistan journal of medical sciences · 2026. Summary drawn from the study's full text. Each statement is followed by the exact sentence it comes from. This is a research summary, not medical advice.

Study type

Prospective, randomized, double-blind study
“This prospective, randomized, double-blind study was conducted at Van Yuzuncu Yil University Dursun Odabaş Medical Center between 2023 and 2024 and included 100 patients undergoing elective cesarean delivery.”

Subjects

Patients undergoing elective cesarean delivery under general anesthesia
“Patients aged 18–40 years with American Society of Anesthesiologists (ASA) physical status II who underwent elective cesarean delivery under general anesthesia were included.”

Sample size

100 patients (50 per group)
“A total of one hundred patients were randomized into two equal groups (n=50) using the sealed envelope technique.”

Duration

Conducted between December 2023 and September 2024
“The study was conducted between December 2023 to September 2024 at the Department of Anesthesiology and Reanimation, in collaboration with the Department of Obstetrics and Gynecology at Van Yuzuncu Yil University Dursun Odabaş Medical Center and included 100 patients scheduled for elective cesarean section.”

Reported findings

Intraoperative blood loss was significantly lower in the carbetocin group than in the oxytocin group
“Intraoperative blood loss was significantly lower in the carbetocin group than in the oxytocin group (p<0.001).”
The need for additional uterotonic agents was significantly lower in the carbetocin group throughout surgery
“The need for additional uterotonic agents was significantly lower in the carbetocin group both within the first 5 minutes (2% vs. 12%) and throughout surgery (10% vs. 26%) (p<0.05 for both).”
Uterine tone was significantly higher in the carbetocin group at 5 minutes, while higher scores were observed in the oxytocin group at 10 minutes
“Uterine tone was significantly higher in the carbetocin group at 5 minutes (p=0.016), whereas higher scores were observed in the oxytocin group at 10 minutes (p=0.034).”

Limitations stated by the authors

Single-center design, limited to elective cesarean delivery under general anesthesia, and lack of long-term maternal and neonatal outcome assessment
“The study was conducted at a single center and included only patients undergoing elective cesarean delivery under general anesthesia, which may limit the generalizability of the findings.”

Source: PubMed 42819600 · DOI 10.12669/pjms.42.9.13879 · all study summaries

Duration

Conducted between December 2023 and September 2024

“The study was conducted between December 2023 to September 2024 at the Department of Anesthesiology and Reanimation, in collaboration with the Department of Obstetrics and Gynecology at Van Yuzuncu Yil University Dursun Odabaş Medical Center and included 100 patients scheduled for elective cesarean section.”

Reported findings

Intraoperative blood loss was significantly lower in the carbetocin group than in the oxytocin group

“Intraoperative blood loss was significantly lower in the carbetocin group than in the oxytocin group (p<0.001).”

The need for additional uterotonic agents was significantly lower in the carbetocin group throughout surgery

“The need for additional uterotonic agents was significantly lower in the carbetocin group both within the first 5 minutes (2% vs. 12%) and throughout surgery (10% vs. 26%) (p<0.05 for both).”

Uterine tone was significantly higher in the carbetocin group at 5 minutes, while higher scores were observed in the oxytocin group at 10 minutes

“Uterine tone was significantly higher in the carbetocin group at 5 minutes (p=0.016), whereas higher scores were observed in the oxytocin group at 10 minutes (p=0.034).”

Limitations stated by the authors

Single-center design, limited to elective cesarean delivery under general anesthesia, and lack of long-term maternal and neonatal outcome assessment

“The study was conducted at a single center and included only patients undergoing elective cesarean delivery under general anesthesia, which may limit the generalizability of the findings.”