Oxytocin · research summary

Agomelatine ameliorates abortion-related alterations in rats: Insights from behavioural, biochemical and histological analyses.

Experimental physiology · 2026. Summary drawn from the study's full text. Each statement is followed by the exact sentence it comes from. This is a research summary, not medical advice.

Study type

Experimental animal study investigating agomelatine in an abortion model
“In this context, this study investigates agomelatine's therapeutic potential in an abortion model across behavioural, biochemical and histological parameters.”

Subjects

Female Sprague–Dawley rats
“Eighty female Sprague–Dawley rats were randomized into eight groups: control, sham, abortion, melatonin (M), agomelatine (A), progesterone (P) and combinations (MP, AP).”

Sample size

80 rats total, with 10 animals per group
“A total of eight experimental groups were established, with 10 animals in each group.”

Duration

14 days of treatment starting from gestational day 0
“Following pregnancy (Day 0), oral treatments were administered daily for 14 days.”

Reported findings

Agomelatine combined with progesterone reduced immobility time in the forced swimming test compared to the abortion group
“The forced swimming test showed shorter immobility time in the AP group compared to the abortion group.”
Agomelatine combined with progesterone lowered serum prostaglandin F2α levels compared to the abortion group
“An enzyme‐linked immunosorbent Assay revealed lower serum prostaglandin F2α level in the AP group and lower serum oxytocin levels in the M, A, MP and AP groups versus the abortion group.”
Treatment groups showed higher histological scores for complete fetus and decidual integrity compared to the abortion group
“Histologically, M, A, P, MP and AP groups exhibited higher scores for complete fetus, decidual congestion, decidual inflammation and cytotrophoblast–syncytiotrophoblast cells compared to the abortion group.”

Source: PubMed 42832729 · DOI 10.1113/EP093951 · all study summaries

Reported findings

Agomelatine combined with progesterone reduced immobility time in the forced swimming test compared to the abortion group

“The forced swimming test showed shorter immobility time in the AP group compared to the abortion group.”

Agomelatine combined with progesterone lowered serum prostaglandin F2α levels compared to the abortion group

“An enzyme‐linked immunosorbent Assay revealed lower serum prostaglandin F2α level in the AP group and lower serum oxytocin levels in the M, A, MP and AP groups versus the abortion group.”

Treatment groups showed higher histological scores for complete fetus and decidual integrity compared to the abortion group

“Histologically, M, A, P, MP and AP groups exhibited higher scores for complete fetus, decidual congestion, decidual inflammation and cytotrophoblast–syncytiotrophoblast cells compared to the abortion group.”