Increased Allergy Susceptibility Associated with Semaglutide, a Glucagon-like Peptide-1 Receptor Agonist.

Case report of a single patient

“In the present case, it is considered that semaglutide acted as a dependent factor, and allergic symptoms were elicited in the presence of additional triggers.”

A 55-year-old man with diabetes mellitus, dyslipidemia, and angina pectoris

“A 55-year-old man with a medical history of diabetes mellitus, dyslipidemia, and angina pectoris, and known allergies to alcohol and bupivacaine, was newly receiving treatment with semaglutide”

1

“In the present case, it is considered that semaglutide acted as a dependent factor, and allergic symptoms were elicited in the presence of additional triggers.”

Observation over approximately 9 months including 3 months post-discontinuation

“After discontinuation of semaglutide, no episodes of urticaria or anaphylaxis were observed over the subsequent 3 months.”

Repeated anaphylactic shock and idiopathic urticaria occurred after semaglutide initiation

“Approximately 2 weeks, 1 and 5 months after the initiation of semaglutide, he repeatedly developed anaphylactic shock.”

Symptoms ceased after discontinuation of semaglutide

“After discontinuation of semaglutide, no episodes of urticaria or anaphylaxis were observed over the subsequent 3 months.”

Glucagon administration restored measurable blood pressure when adrenaline was ineffective

“After administration of 1 mg glucagon, his blood pressure became measurable.”

Single case report with speculative mechanism and no similar reported cases

“To the best of our knowledge, no similar cases have been reported to date.”