Semaglutide · research summary

Chronic semaglutide treatment attenuates cue-induced reinstatement of cocaine-seeking and cocaine-induced stereotypy in male and female rats.

bioRxiv : the preprint server for biology · 2026. Summary drawn from the study's full text. Each statement is followed by the exact sentence it comes from. This is a research summary, not medical advice.

Study type

Animal study involving cocaine self-administration and reinstatement tests
“Following cocaine self-administration, male and female rats received daily semaglutide during a 30-day abstinence period before cue- and cocaine-induced reinstatement tests.”

Subjects

Male and female rats
“Following cocaine self-administration, male and female rats received daily semaglutide during a 30-day abstinence period before cue- and cocaine-induced reinstatement tests.”

Duration

30-day abstinence period
“Following cocaine self-administration, male and female rats received daily semaglutide during a 30-day abstinence period before cue- and cocaine-induced reinstatement tests.”

Reported findings

Semaglutide attenuated cue-induced reinstatement
“Semaglutide attenuated cue-induced reinstatement and cocaine-induced stereotypy, although operant responding was elevated following cocaine priming.”
Semaglutide attenuated cocaine-induced stereotypy
“Semaglutide attenuated cue-induced reinstatement and cocaine-induced stereotypy, although operant responding was elevated following cocaine priming.”
Operant responding was elevated following cocaine priming
“Semaglutide attenuated cue-induced reinstatement and cocaine-induced stereotypy, although operant responding was elevated following cocaine priming.”

Source: PubMed 42856215 · DOI 10.64898/2026.09.21.753157 · all study summaries