Long-term metabolic regulation in the era of GLP-1 receptor agonists: An integrative review of Ayurvedic and biomedical perspectives.

Integrative review

“Long-term metabolic regulation in the era of GLP-1 receptor agonists: An integrative review of Ayurvedic and biomedical perspectives.”

Semaglutide demonstrates efficacy in improving glycemic control, weight loss, and reducing cardiovascular and renal risk.

“Among them, semaglutide has demonstrated robust efficacy in improving glycemic control, inducing clinically meaningful weight loss, and reducing cardiovascular and renal risk in high-risk populations through well-established molecular and physiological mechanisms.”

Challenges to long-term metabolic sustainability include weight regain after discontinuation and loss of lean mass.

“Despite these benefits, challenges related to long-term metabolic sustainability persist, including weight regain after discontinuation, loss of lean mass defined as the reduction in skeletal muscle and non-adipose body tissue and the need for prolonged or lifelong therapy.”

The paper argues for a complementary model where pharmacotherapy stabilizes acute risk while integrative strategies support sustained health.

“Rather than positioning traditional knowledge systems in opposition to evidence-based medicine, this paper argues for a complementary model in which pharmacotherapy stabilizes acute metabolic risk while integrative lifestyle-oriented strategies support sustained metabolic health.”